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AM-1248 is a drug that acts as a moderately potent agonist (https://en.wikipedia.org/wiki/Agonist) for both the cannabinoid receptors (https://en.wikipedia.org/wiki/Cannabinoid_receptor) CB1 (https://en.wikipedia.org/wiki/Cannabinoid_receptor_1) and CB2 (https://en.wikipedia.org/wiki/Cannabinoid_receptor_2), but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an adamant (https://en.wikipedia.org/wiki/Adamantane)oyl (https://en.wikipedia.org/wiki/Ketone) group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position.